GPX4 and EGR4

Data Source:
BioGRID (biochemical)

		GPX4	EGR4
Description		glutathione peroxidase 4	early growth response 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	NGF-stimulated transcription
Drugs		Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)	Age at voice drop ( 27182965) Blood metabolite levels ( 26401656)
Interacting Genes		3 interacting genes: MAPK13 PARK7 PRDX6	5 interacting genes: ABI2 BAG3 CRBN DNMT3L NFATC2
Entrez ID		2879	1961
HPRD ID		11819	00550
Ensembl ID		ENSG00000167468	ENSG00000135625
Uniprot IDs		P36969 Q6PI42	B7ZKU3 Q05215
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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