GMPR and CD83

Data Source:
BioGRID (biochemical)

		GMPR	CD83
Description		guanosine monophosphate reductase	CD83 molecule
Image
GO Annotations	Cellular Component	Cytosol GMP Reductase Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	GMP Reductase Activity Metal Ion Binding	Protein Binding
	Biological Process	Purine Nucleobase Metabolic Process Purine Nucleotide Metabolic Process Response To Cold Purine-containing Compound Salvage	Defense Response Humoral Immune Response Signal Transduction Response To Organic Cyclic Compound Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Pathways		Purine salvage
Drugs		Guanosine-5'-Monophosphate
Diseases
GWAS		Blood metabolite levels ( 24816252) Gambling ( 22780124) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean spheric corpuscular volume ( 32888494) QT interval ( 24952745 29874175) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 30423114 22446963 24390342)
Interacting Genes			2 interacting genes: EIF4E FATE1
Entrez ID		2766	9308
HPRD ID		00754	05170
Ensembl ID		ENSG00000137198	ENSG00000112149
Uniprot IDs		P36959	A0A087WX61 Q01151
PDB IDs		2BLE 2BWG	5MIX 5MJ0 5MJ1 5MJ2
Enriched GO Terms of Interacting Partners?
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