MAT2B and YTHDF3

Data Source:
BioGRID (affinity chromatography technology)

		MAT2B	YTHDF3
Description		methionine adenosyltransferase 2B	YTH N6-methyladenosine RNA binding protein 3
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GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity	Positive Regulation Of Translation Positive Regulation Of Translational Initiation Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Myocardial infarction ( 26708285) Smoking behaviour (cigarettes smoked per day) ( 30679032) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: APP FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	2 interacting genes: FAF1 ZDHHC17
Entrez ID		27430	253943
HPRD ID		05701	08106
Ensembl ID		ENSG00000038274	ENSG00000185728
Uniprot IDs		A0A140VJP2 Q9NZL9	A0A024R7W5 A0A087WY31 B4DPX9 Q658Z6 Q7Z739 Q8N3V9 Q8NA80
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	6ZOT
Enriched GO Terms of Interacting Partners?
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