GLE1 and SYNE2

Data Source:
BioGRID (affinity chromatography technology)

		GLE1	SYNE2
Description		GLE1 RNA export mediator	spectrin repeat containing nuclear envelope protein 2
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GO Annotations	Cellular Component	Extracellular Space Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Ciliary Basal Body Nuclear Pore Cytoplasmic Filaments	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Inositol Hexakisphosphate Binding Protein Binding Phospholipid Binding Translation Initiation Factor Binding Identical Protein Binding	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	MRNA Export From Nucleus Regulation Of Translational Initiation Regulation Of Translational Termination Poly(A)+ MRNA Export From Nucleus	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript	Meiotic synapsis
Drugs
Diseases		Lethal arthrogryposis with anterior horn cell disease Lethal congenital contractural syndrome (LCCS)	Emery-Dreifuss muscular dystrophy
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: KRT10 NUP155 NUP42 UXT	11 interacting genes: ABI1 ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML SASH1 UBC
Entrez ID		2733	23224
HPRD ID		04536	09763
Ensembl ID		ENSG00000119392	ENSG00000054654
Uniprot IDs		B3KMG0 Q53GS7	Q6MZP0 Q8WXH0
PDB IDs		6B4F 6B4I 6B4J	4DXS 4FI9
Enriched GO Terms of Interacting Partners?
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