FAM184B and WFS1

Data Source:
BioGRID (two hybrid)

		FAM184B	WFS1
Description		family with sequence similarity 184 member B	wolframin ER transmembrane glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite
	Molecular Function		Protein Binding Ubiquitin Protein Ligase Binding ATPase Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Height ( 28552196 25429064) Platelet count ( 32888494) Plateletcrit ( 32888494)	Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes			11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1
Entrez ID		27146	7466
HPRD ID		19526	05864
Ensembl ID		ENSG00000047662	ENSG00000109501
Uniprot IDs		Q9ULE4	A0A0S2Z4V6 O76024
PDB IDs
Enriched GO Terms of Interacting Partners?
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