NPHP3 and DDX3Y

Data Source:
HPRD (in vitro)

		NPHP3	DDX3Y
Description		nephrocystin 3	DEAD-box helicase 3 Y-linked
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium	Nucleus Nucleoplasm Cytosol Membrane P Granule
	Molecular Function	Protein Binding	DNA Binding RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure	Gamete Generation Cell Differentiation
Pathways		Trafficking of myristoylated proteins to the cilium
Drugs
Diseases		Senior-Loken syndrome Renal-hepatic-pancreatic dysplasia Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Subcortical volume (MOSTest) ( 32665545)	Autism ( 32996047)
Interacting Genes		3 interacting genes: ATXN1 DYSF NPHP1	21 interacting genes: MIR106A MIR106B MIR107 MIR128-2 MIR143 MIR15B MIR18B MIR19B2 MIR20A MIR25 MIR31 MIR34A MIR363 MIR7-1 MIR7-2 MIR98 MIRLET7B MIRLET7D MIRLET7F1 MIRLET7G SHBG
Entrez ID		27031	8653
HPRD ID		06417	02452
Ensembl ID		ENSG00000113971	ENSG00000067048
Uniprot IDs		Q7Z494	A0A024R9A4 O15523
PDB IDs		5L7K
Enriched GO Terms of Interacting Partners?
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