NPHP3 and DPP7

Data Source:
BioGRID (affinity chromatography technology)

		NPHP3	DPP7
Description		nephrocystin 3	dipeptidyl peptidase 7
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium	Extracellular Region Golgi Apparatus Cytosol Vesicle Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding	Aminopeptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure	Proteolysis Neutrophil Degranulation
Pathways		Trafficking of myristoylated proteins to the cilium	Neutrophil degranulation
Drugs
Diseases		Senior-Loken syndrome Renal-hepatic-pancreatic dysplasia Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 29875488) Pursuit maintenance gain ( 29064472)
Interacting Genes		3 interacting genes: ATXN1 DYSF NPHP1	1 interacting genes: XRN1
Entrez ID		27031	29952
HPRD ID		06417	07634
Ensembl ID		ENSG00000113971	ENSG00000176978
Uniprot IDs		Q7Z494	Q9UHL4
PDB IDs		5L7K	3JYH 3N0T 4EBB
Enriched GO Terms of Interacting Partners?
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