NPHP3 and DNAJC13

Data Source:
BioGRID (unspecified method)

		NPHP3	DNAJC13
Description		nephrocystin 3	DnaJ heat shock protein family (Hsp40) member C13
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium	Lysosomal Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome WASH Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Determination Of Left/right Symmetry Wnt Signaling Pathway Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure	Osteoblast Differentiation Receptor-mediated Endocytosis Endosome Organization Protein Transport Neutrophil Degranulation Regulation Of Early Endosome To Recycling Endosome Transport Regulation Of Early Endosome To Late Endosome Transport
Pathways		Trafficking of myristoylated proteins to the cilium	Neutrophil degranulation
Drugs
Diseases		Senior-Loken syndrome Renal-hepatic-pancreatic dysplasia Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 27182965 21102462) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 30275531) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: ATXN1 DYSF NPHP1	6 interacting genes: CALM1 CLK1 DNAJB11 GADD45A GSK3B RPS6KA6
Entrez ID		27031	23317
HPRD ID		06417	10915
Ensembl ID		ENSG00000113971	ENSG00000138246
Uniprot IDs		Q7Z494	B3KN02 O75165
PDB IDs		5L7K
Enriched GO Terms of Interacting Partners?
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