GBP2 and LRRC8B

Data Source:
HPRD (in vivo, in vitro)

		GBP2	LRRC8B
Description		guanylate binding protein 2	leucine rich repeat containing 8 VRAC subunit B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Homodimerization Activity	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Immune Response Protein Localization To Nucleus Defense Response To Protozoan Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG
Entrez ID		2634	23507
HPRD ID		02682	18145
Ensembl ID		ENSG00000162645	ENSG00000197147
Uniprot IDs		P32456 Q8TCE5	A0A384N5V6 Q6P9F7
PDB IDs
Enriched GO Terms of Interacting Partners?
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