NPHP4 and C1orf127

Data Source:
BioGRID (affinity chromatography technology)

		NPHP4	C1orf127
Description		nephrocystin 4	chromosome 1 open reading frame 127
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium
	Molecular Function	Structural Molecule Activity Protein Binding
	Biological Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone	Heart Development
Pathways		Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)	Beard thickness ( 26926045) Blond vs. brown/black hair color ( 30531825) Excessive hairiness ( 29895819) Male-pattern baldness ( 27182965 28196072)
Interacting Genes		2 interacting genes: NPHP1 RPGRIP1
Entrez ID		261734	148345
HPRD ID		06238	08780
Ensembl ID		ENSG00000131697	ENSG00000175262
Uniprot IDs		B3KW36 O75161	B7ZLG7 G8JLG8
PDB IDs
Enriched GO Terms of Interacting Partners?
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