NPHP4 and EDIL3

Data Source:
BioGRID (biochemical)

		NPHP4	EDIL3
Description		nephrocystin 4	EGF like repeats and discoidin domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium	Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Structural Molecule Activity Protein Binding	Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding
	Biological Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone	Cell Adhesion Multicellular Organism Development Positive Regulation Of Cell-substrate Adhesion
Pathways		Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)	Alzheimer's disease biomarkers ( 23419831) Ankylosing spondylitis ( 22138694) Anxiety and stress-related disorders ( 31116379) Asthma and hay fever ( 24388013) Blood trace element (Cu levels) ( 23720494) Chemerin levels ( 20237162) Loneliness ( 27629369) Mitochondrial DNA levels ( 25240745) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1/FVC ratio ( 26634245) Uterine fibroid size (maximum dimension) ( 30196971)
Interacting Genes		2 interacting genes: NPHP1 RPGRIP1	1 interacting genes: ITGAV
Entrez ID		261734	10085
HPRD ID		06238	09350
Ensembl ID		ENSG00000131697	ENSG00000164176
Uniprot IDs		B3KW36 O75161	O43854
PDB IDs			4D90
Enriched GO Terms of Interacting Partners?
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