GAMT and GPX4

Data Source:
HPRD (in vitro, in vivo)

		GAMT	GPX4
Description		guanidinoacetate N-methyltransferase	glutathione peroxidase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Guanidinoacetate N-methyltransferase Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Creatine metabolism Transcriptional Regulation by MECP2	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine	Glutathione Glutathione Glutathione disulfide
Diseases		Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS) Guanidinoacetate methyltransferase (GAMT) deficiency
GWAS			Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CSNK2B FOS POT1 RAB24 TERF1 TERF2IP TRIM39	3 interacting genes: MAPK13 PARK7 PRDX6
Entrez ID		2593	2879
HPRD ID		03142	11819
Ensembl ID		ENSG00000130005	ENSG00000167468
Uniprot IDs		Q14353 V9HWB2	P36969 Q6PI42
PDB IDs		3ORH	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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