GALR1 and CD226

Data Source:
BioGRID (affinity chromatography technology)

		GALR1	CD226
Description		galanin receptor 1	CD226 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft
	Molecular Function	Galanin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Neuropeptide Binding	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cortisol Secretion	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Type I diabetes mellitus
GWAS		Blood osmolality (transformed sodium) ( 28360221) Height ( 31562340) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Smoking initiation (ever regular vs never regular) ( 31089300)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 22139419 19820697 31194788 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 21829393 25751624 17554260) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: GAL SNAPC5	4 interacting genes: FYN ITGB2 NECTIN2 PVR
Entrez ID		2587	10666
HPRD ID		02657	09252
Ensembl ID		ENSG00000166573	ENSG00000150637
Uniprot IDs		P47211	J3QR77 Q15762
PDB IDs			6ISB 6O3O
Enriched GO Terms of Interacting Partners?
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