FBXL2 and DYNC1LI1

Data Source:
BioGRID (genetic interference)

		FBXL2	DYNC1LI1
Description		F-box and leucine rich repeat protein 2	dynein cytoplasmic 1 light intermediate chain 1
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GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	RNA Binding Motor Activity Protein Binding ATP Binding GTP Binding GDP Binding Dynein Heavy Chain Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Cell Cycle Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Degranulation Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Rostral anterior cingulate cortex volume ( 31530798)	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 ITPR3 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1	7 interacting genes: BRCA2 IKBKG NOP56 NUP85 PGAM2 RAB4A REL
Entrez ID		25827	51143
HPRD ID		05736	10917
Ensembl ID		ENSG00000153558	ENSG00000144635
Uniprot IDs		Q9UKC9	E9PHI6 Q9Y6G9
PDB IDs		6O60	6B9H 6PSE
Enriched GO Terms of Interacting Partners?
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