RASGRP3 and DYNC2LI1

Data Source:
BioGRID (genetic interference)

		RASGRP3	DYNC2LI1
Description		RAS guanyl releasing protein 3	dynein cytoplasmic 2 light intermediate chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Centrosome Cytoplasmic Dynein Complex Cytoplasmic Microtubule Cilium Axoneme Intraciliary Transport Particle Motile Cilium Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Ciliary Tip
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Kinase Binding Diacylglycerol Binding Small GTPase Binding	Motor Activity Protein Binding Dynein Heavy Chain Binding
	Biological Process	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of GTPase Activity	Determination Of Left/right Symmetry Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Regulation Of Cilium Assembly
Pathways		Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade	Intraflagellar transport
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 28714469 19838193)	Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	2 interacting genes: DCDC2 DYNC2H1
Entrez ID		25780	51626
HPRD ID		15213	13116
Ensembl ID		ENSG00000152689	ENSG00000138036
Uniprot IDs		Q8IV61	Q8TCX1
PDB IDs			6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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