SERINC5 and FXR1

Data Source:
HPRD (in vitro)

		SERINC5	FXR1
Description		serine incorporator 5	FMR1 autosomal homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Centrosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Myelin Sheath Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Costamere Dendritic Spine Dendritic Spine Neck Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse Dendritic Filopodium
	Molecular Function		RNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity
	Biological Process	L-serine Biosynthetic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Detection Of Virus Viral Process Myelination Innate Immune Response Defense Response To Virus Positive Regulation Of CDP-diacylglycerol-serine O-phosphatidyltransferase Activity Positive Regulation Of Serine C-palmitoyltransferase Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Skeletal Muscle Organ Development Positive Regulation Of Gene Silencing By MiRNA Positive Regulation Of Response To DNA Damage Stimulus
Pathways		Serine biosynthesis	Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Borderline personality disorder features ( 23979607) Fasting blood glucose ( 28371326) Sulfasalazine-induced agranulocytosis ( 28762467)	Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Metabolite levels ( 23823483) Schizophrenia ( 25056061 19571811 29483656 30285260)
Interacting Genes		1 interacting genes: PTAFR	48 interacting genes: AP1M1 BLK BYSL C1orf35 CBX8 CCDC187 CDC7 CDKL3 CEP126 CRMP1 CSNK2A1 CWF19L2 CYFIP2 DHX15 ELOA ERCC6 ERG28 ESCO2 FAM161A FAM90A1 FBXO4 FMR1 FXR2 GBP2 HSPB1 KIF9 LNX1 LRIF1 LUC7L2 MAGOH MAGOHB MCRS1 MFAP1 PRAM1 PRPF31 PRSS23 SRPK2 STK16 SUFU SYT6 TBC1D22B TCEA2 TRPM1 YES1 ZMAT2 ZNF417 ZNF438 ZNF71
Entrez ID		256987	8087
HPRD ID		12828	02892
Ensembl ID		ENSG00000164300	ENSG00000114416
Uniprot IDs		Q86VE9	A0A0F7KYT8 A0A0F7L1S3 P51114
PDB IDs			2CPQ 3KUF 3O8V
Enriched GO Terms of Interacting Partners?
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