RICTOR and PHKB

Data Source:
BioGRID (affinity chromatography technology)

		RICTOR	PHKB
Description		RPTOR independent companion of MTOR complex 2	phosphorylase kinase regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol TORC2 Complex	Cytosol Plasma Membrane Phosphorylase Kinase Complex
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity	Protein Binding Calmodulin Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity	Glycogen Metabolic Process Glycogen Catabolic Process Generation Of Precursor Metabolites And Energy Protein Phosphorylation
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation	Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1	5 interacting genes: C20orf27 CALM1 CAMK2B HNRNPC PHKA2
Entrez ID		253260	5257
HPRD ID		10682	01407
Ensembl ID		ENSG00000164327	ENSG00000102893
Uniprot IDs		Q6R327	Q93100
PDB IDs		5ZCS
Enriched GO Terms of Interacting Partners?
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