RICTOR and PLCXD3

Data Source:
BioGRID (two hybrid)

		RICTOR	PLCXD3
Description		RPTOR independent companion of MTOR complex 2	phosphatidylinositol specific phospholipase C X domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol TORC2 Complex	Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity	Protein Binding Phosphoric Diester Hydrolase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity	Signal Transduction Lipid Catabolic Process
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1	2 interacting genes: MAGEA11 P4HB
Entrez ID		253260	345557
HPRD ID		10682	17860
Ensembl ID		ENSG00000164327	ENSG00000182836
Uniprot IDs		Q6R327	B3KXD1 Q63HM9
PDB IDs		5ZCS
Enriched GO Terms of Interacting Partners?
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