RICTOR and CTSW

Data Source:
BioGRID (biochemical)

		RICTOR	CTSW
Description		RPTOR independent companion of MTOR complex 2	cathepsin W
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol TORC2 Complex	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Membrane Platelet Dense Granule Lumen
	Molecular Function	Protein Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Cell Polarity	Platelet Degranulation Immune Response Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation	Platelet degranulation
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1	1 interacting genes: CREB3
Entrez ID		253260	1521
HPRD ID		10682	03840
Ensembl ID		ENSG00000164327	ENSG00000172543
Uniprot IDs		Q6R327	P56202
PDB IDs		5ZCS
Enriched GO Terms of Interacting Partners?
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