FRK and PRDM1

Data Source:
BioGRID (biochemical)

		FRK	PRDM1
Description		fyn related Src family tyrosine kinase	PR/SET domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Intracellular Anatomical Structure Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Neutrophil Degranulation Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Innate Immune Response Cell Fate Commitment Regulation Of NK T Cell Differentiation
Pathways		Neutrophil degranulation Regulation of PTEN stability and activity	Regulation of TP53 Expression
Drugs		Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Age-related macular degeneration ( 21665990) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 32203549 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 23263486)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2	10 interacting genes: ATXN1 H1-1 H3C15 IKZF3 IRF4 KDM1A PIAS1 TLE1 TLE2 TLE5
Entrez ID		2444	639
HPRD ID		05954	04572
Ensembl ID		ENSG00000111816	ENSG00000057657
Uniprot IDs		P42685	A0A3B3IU23 B4DW27 O75626 Q5T4E8
PDB IDs			3DAL
Enriched GO Terms of Interacting Partners?
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