ALOX5AP and GDF15

Data Source:
HPRD (in vitro)

		ALOX5AP	GDF15
Description		arachidonate 5-lipoxygenase activating protein	growth differentiation factor 15
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification Lipoxin Biosynthetic Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)
Drugs		DG031 AM103 Fiboflapon
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		241	9518
HPRD ID		04742	05608
Ensembl ID		ENSG00000132965	ENSG00000130513
Uniprot IDs		A0A087WW23 P20292	Q99988
PDB IDs		2Q7M 2Q7R	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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