IL17RA and BID

Data Source:
BioGRID (proximity labelling technology)

		IL17RA	BID
Description		interleukin 17 receptor A	BH3 interacting domain death agonist
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane
	Molecular Function	Protein Binding Interleukin-17 Receptor Activity	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-17 signaling	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		2 interacting genes: IL17A MTDH	37 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		23765	637
HPRD ID		10399	03590
Ensembl ID		ENSG00000177663	ENSG00000015475
Uniprot IDs		Q96F46	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		3JVF 4HSA 4NUX 5N9B 5NAN	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F
Enriched GO Terms of Interacting Partners?
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