ARL2BP and FLT1

Data Source:
BioGRID (affinity chromatography technology)

		ARL2BP	FLT1
Description		ADP ribosylation factor like GTPase 2 binding protein	fms related receptor tyrosine kinase 1
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GO Annotations	Cellular Component	Nucleus Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Spindle Cytosol Cilium Midbody	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding GTPase Regulator Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity
	Biological Process	Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression
Pathways		Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization
Drugs			Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 29403010)	Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: ARL2 ARL3 CAMK2D CFAP20 MPP3 RAC1	25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		23568	2321
HPRD ID		09808	01297
Ensembl ID		ENSG00000102931	ENSG00000102755
Uniprot IDs		A0A024R6U9 Q9Y2Y0	L7RSL3 P17948
PDB IDs		2K9A 3DOE 3DOF	1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
Enriched GO Terms of Interacting Partners?
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