POFUT1 and PTPRA

Data Source:
HPRD (in vivo)

		POFUT1	PTPRA
Description		protein O-fucosyltransferase 1	protein tyrosine phosphatase receptor type A
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation	MAPK Cascade Protein Phosphorylation Protein Dephosphorylation Integrin-mediated Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission Regulation Of Focal Adhesion Assembly
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: AKT2 DLL1 JAG1 NOTCH1	17 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		23509	5786
HPRD ID		06319	01476
Ensembl ID		ENSG00000101346	ENSG00000132670
Uniprot IDs		Q9H488	P18433
PDB IDs		5UX6 5UXH	6UZT
Enriched GO Terms of Interacting Partners?
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