SIRT5 and LSS

Data Source:
BioGRID (proximity labelling technology)

		SIRT5	LSS
Description		sirtuin 5	lanosterol synthase
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol	Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Protein-glutaryllysine Deglutarylase Activity NAD+ Binding	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Peptidyl-lysine Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process
Pathways		Transcriptional activation of mitochondrial biogenesis	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol	R048-8071 Lanosterol
Diseases
GWAS		Perceived intensity of sweet substances ( 31005972)	White blood cell count ( 27863252)
Interacting Genes		1 interacting genes: APP	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		23408	4047
HPRD ID		06838	02945
Ensembl ID		ENSG00000124523	ENSG00000160285
Uniprot IDs		A0A024R012 Q9NXA8	B2R694 P48449
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJM 6LJN	1W6J 1W6K
Enriched GO Terms of Interacting Partners?
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