SIRT5 and RNF182

Data Source:
HPRD (in vitro)

		SIRT5	RNF182
Description		sirtuin 5	ring finger protein 182
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol	Cytoplasm Integral Component Of Membrane
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Protein-glutaryllysine Deglutarylase Activity NAD+ Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Peptidyl-lysine Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Ubiquitination
Pathways		Transcriptional activation of mitochondrial biogenesis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol
Diseases
GWAS		Perceived intensity of sweet substances ( 31005972)	Lymphoma ( 23349640) Mean corpuscular hemoglobin concentration ( 27863252) Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: APP	5 interacting genes: UBC UBE2D1 UBE2K UBE2L3 UBE2N
Entrez ID		23408	221687
HPRD ID		06838	15264
Ensembl ID		ENSG00000124523	ENSG00000180537
Uniprot IDs		A0A024R012 Q9NXA8	A0A024QZW5 Q8N6D2
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJM 6LJN
Enriched GO Terms of Interacting Partners?
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