WASHC4 and ANAPC7

Data Source:
BioGRID (affinity chromatography technology)

		WASHC4	ANAPC7
Description		WASH complex subunit 4	anaphase promoting complex subunit 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Early Endosome BLOC-1 Complex WASH Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Microtubule Cytoskeleton
	Molecular Function		Protein Phosphatase Binding
	Biological Process	Endosome Organization Protein Transport Endosomal Transport	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)
Interacting Genes		3 interacting genes: MTNR1A SMAD2 WASHC1	16 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CREBBP FBXO5 FZR1 HSPB1 PTEN PTGER4 UBC UBE2S
Entrez ID		23325	51434
HPRD ID		13829	16233
Ensembl ID		ENSG00000136051	ENSG00000196510
Uniprot IDs		A0A087X256 B7ZKT9 Q2M389	A0A024RBJ3 Q4KMX6 Q69YV3 Q9UJX3
PDB IDs			3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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