SMG6 and SNAI2

Data Source:
BioGRID (genetic interference)

		SMG6	SNAI2
Description		SMG6 nonsense mediated mRNA decay factor	snail family transcriptional repressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding Telomeric DNA Binding Ribonucleoprotein Complex Binding Metal Ion Binding Telomerase RNA Binding DNA Polymerase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation Regulation Of Telomerase Activity RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Negative Regulation Of Telomere Capping	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Notch Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Vitamin D Biosynthetic Process Neural Crest Cell Development Positive Regulation Of Cell Migration Negative Regulation Of Chondrocyte Differentiation Regulation Of Chemokine Production Negative Regulation Of Cell Adhesion Mediated By Integrin Desmosome Disassembly Pigmentation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Osteoblast Differentiation Epithelium Development Notch Signaling Involved In Heart Development Negative Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs		Grn163l
Diseases			Piebaldism Waardenburg syndrome (WS)
GWAS		Aortic root size ( 19584346) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Calcaneus stiffness index ( 30779856) Cannabis use ( 30150663) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414 32239398 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Forehead morphology ( 29921221) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998 29235454) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Metabolite levels (5-HIAA) ( 23319000) Mitral valve prolapse ( 26301497) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 31420334) White blood cell count ( 32888494 27863252)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252)
Interacting Genes		4 interacting genes: MEOX2 PPP1CC SMG5 TERT	11 interacting genes: APP CABP2 CSNK2A1 PIAS1 PIAS2 PIAS3 PIAS4 SAT1 TRIM23 UBE2I ZNF76
Entrez ID		23293	6591
HPRD ID		06502	03689
Ensembl ID		ENSG00000070366	ENSG00000019549
Uniprot IDs		Q86US8	O43623
PDB IDs		2DOK 2HWW 2HWX 4UM2
Enriched GO Terms of Interacting Partners?
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