SYNE2 and GLE1

Data Source:
BioGRID (affinity chromatography technology)

		SYNE2	GLE1
Description		spectrin repeat containing nuclear envelope protein 2	GLE1 RNA export mediator
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome	Extracellular Space Nuclear Envelope Nuclear Pore Nucleolus Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Ciliary Basal Body Nuclear Pore Cytoplasmic Filaments
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Inositol Hexakisphosphate Binding Protein Binding Phospholipid Binding Translation Initiation Factor Binding Identical Protein Binding
	Biological Process	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly	MRNA Export From Nucleus Regulation Of Translational Initiation Regulation Of Translational Termination Poly(A)+ MRNA Export From Nucleus
Pathways		Meiotic synapsis	Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases		Emery-Dreifuss muscular dystrophy	Lethal arthrogryposis with anterior horn cell disease Lethal congenital contractural syndrome (LCCS)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 28416818 30061737 29892015 22544366) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		11 interacting genes: ABI1 ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML SASH1 UBC	4 interacting genes: KRT10 NUP155 NUP42 UXT
Entrez ID		23224	2733
HPRD ID		09763	04536
Ensembl ID		ENSG00000054654	ENSG00000119392
Uniprot IDs		Q6MZP0 Q8WXH0	B3KMG0 Q53GS7
PDB IDs		4DXS 4FI9	6B4F 6B4I 6B4J
Enriched GO Terms of Interacting Partners?
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