MDN1 and FADS3

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)

		MDN1	FADS3
Description		midasin AAA ATPase 1	fatty acid desaturase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Membrane Preribosome, Large Subunit Precursor Intermediate Filament Cytoskeleton	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Unfolded Protein Binding	Molecular_function Protein Binding Oxidoreductase Activity
	Biological Process	Ribosomal Large Subunit Assembly RRNA Processing Protein-containing Complex Assembly	Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Coronary artery disease ( 29212778) QRS interval (sulfonylurea treatment interaction) ( 27958378)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 25961943 20686565) Fatty acid desaturase activity (serum) ( 30453627) Glycerophospholipid levels ( 26068415) HDL cholesterol ( 24097068 19060906 19060911 25961943 20686565) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060911 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23823483 23378610 22916037) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 19798445 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 19060906 25961943 20686565) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: AR PTEN SUMO2 UBC	1 interacting genes: DHRSX
Entrez ID		23195	3995
HPRD ID		10069	07547
Ensembl ID		ENSG00000112159	ENSG00000221968
Uniprot IDs		Q9NU22	A0A024R564 Q9Y5Q0
PDB IDs
Enriched GO Terms of Interacting Partners?
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