PLXND1 and TMCC1

Data Source:
BioGRID (affinity chromatography technology)

		PLXND1	TMCC1
Description		plexin D1	transmembrane and coiled-coil domain family 1
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Integral Component Of Membrane Endoplasmic Reticulum-endosome Membrane Contact Site
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding	Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Positive Regulation Of Transcription Of Notch Receptor Target Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission
Pathways		Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Breast size ( 22747683) Height ( 28552196) Type 2 diabetes ( 30297969) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: HOXB5 MACF1 SEMA4A	2 interacting genes: APP ZDHHC17
Entrez ID		23129	23023
HPRD ID		05046	15518
Ensembl ID		ENSG00000004399	ENSG00000172765
Uniprot IDs		Q9Y4D7	E9PC87 O94876
PDB IDs		3H6N
Enriched GO Terms of Interacting Partners?
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