RAP1GAP2 and SMG6

Data Source:
BioGRID (affinity chromatography technology)

		RAP1GAP2	SMG6
Description		RAP1 GTPase activating protein 2	SMG6 nonsense mediated mRNA decay factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Binding Endoribonuclease Activity Protein Binding Telomeric DNA Binding Ribonucleoprotein Complex Binding Metal Ion Binding Telomerase RNA Binding DNA Polymerase Binding
	Biological Process	Regulation Of Cell Size Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation Regulation Of Telomerase Activity RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Negative Regulation Of Telomere Capping
Pathways		Rap1 signalling	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Grn163l
Diseases
GWAS		Asthma (sex interaction) ( 24824216) Basophil count ( 32888494) Eosinophil counts ( 32888494) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pre-treatment viral load in HIV-1 infection ( 31219150) Prepulse inhibition of the startle response ( 31596458) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)	Aortic root size ( 19584346) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Calcaneus stiffness index ( 30779856) Cannabis use ( 30150663) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414 32239398 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Forehead morphology ( 29921221) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998 29235454) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Metabolite levels (5-HIAA) ( 23319000) Mitral valve prolapse ( 26301497) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 31420334) White blood cell count ( 32888494 27863252)
Interacting Genes		3 interacting genes: MEOX2 YWHAE YWHAZ	4 interacting genes: MEOX2 PPP1CC SMG5 TERT
Entrez ID		23108	23293
HPRD ID		17028	06502
Ensembl ID		ENSG00000132359	ENSG00000070366
Uniprot IDs		A0A1B0GV05 Q684P5	Q86US8
PDB IDs			2DOK 2HWW 2HWX 4UM2
Enriched GO Terms of Interacting Partners?
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