ERC1 and FPR2

Data Source:
BioGRID (affinity chromatography technology)

		ERC1	FPR2
Description		ELKS/RAB6-interacting/CAST family member 1	formyl peptide receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Centrosome IkappaB Kinase Complex Ciliary Basal Body Presynaptic Membrane Synapse Cytoskeleton Of Presynaptic Active Zone	Cytoplasm Plasma Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Leucine Zipper Domain Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Phosphorylation Neuromuscular Synaptic Transmission Multicellular Organism Development Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Cellular Response To Amyloid-beta
Pathways			G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867)	Alopecia areata ( 25608926) Multiple sclerosis ( 31604244 24076602) Tourette syndrome ( 30818990)
Interacting Genes		9 interacting genes: APP DNAJC5 ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 YWHAG	5 interacting genes: APOD CAMP FXYD6 LRRC25 SSMEM1
Entrez ID		23085	2358
HPRD ID		06181	00647
Ensembl ID		ENSG00000082805	ENSG00000171049
Uniprot IDs		G8JLD3 Q8IUD2 X6RLX0	A0A024R4P3 P25090
PDB IDs			6LW5 6OMM
Enriched GO Terms of Interacting Partners?
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