MYCBP2 and EDNRB

Data Source:
BioGRID (affinity chromatography technology)

		MYCBP2	EDNRB
Description		MYC binding protein 2	endothelin receptor type B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Membrane Axon Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Neuromuscular Process Regulation Of Cytoskeleton Organization Regulation Of Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway Response To Endothelin
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases			Hirschsprung disease (HD) ABCD syndrome Nasopharyngeal cancer Waardenburg syndrome (WS)
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		15 interacting genes: APPL1 ATP13A2 CALM1 ERBB3 FBXO45 MYC NMNAT2 PTPN12 SRPK2 TTN UBE2D2 UBE2D3 UBE2L3 YWHAG YWHAQ	7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3
Entrez ID		23077	1910
HPRD ID		10104	08834
Ensembl ID		ENSG00000005810	ENSG00000136160
Uniprot IDs		O75592	A0A024R638 A0A024R645 P24530
PDB IDs		5O6C 6T7F	5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY
Enriched GO Terms of Interacting Partners?
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