FOXC1 and TOMM70

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		FOXC1	TOMM70
Description		forkhead box C1	translocase of outer mitochondrial membrane 70
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Sequence-specific DNA Binding Promoter-specific Chromatin Binding	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Eye Development Ureteric Bud Development In Utero Embryonic Development Somitogenesis Kidney Development Lymph Vessel Development Endochondral Ossification Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Heart Development Cell Population Proliferation Germ Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Neural Crest Cell Development Cell Migration Negative Regulation Of Angiogenesis Cerebellum Development Cell Differentiation Collagen Fibril Organization Glycosaminoglycan Metabolic Process Lacrimal Gland Development Embryonic Heart Tube Development Maintenance Of Lens Transparency Vascular Endothelial Growth Factor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Glomerular Epithelium Development Blood Vessel Diameter Maintenance Negative Regulation Of Lymphangiogenesis Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Core Promoter Binding Cellular Response To Chemokine	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Cellular Response To Virus
Pathways			Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 26752265) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 26752265 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 31959993 30054594) Monobrow thickness ( 26926045) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Systolic blood pressure ( 30224653)
Interacting Genes		1 interacting genes: HMGB1	7 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 PRKN SNAPIN
Entrez ID		2296	9868
HPRD ID		03054	16194
Ensembl ID		ENSG00000054598	ENSG00000154174
Uniprot IDs		Q12948 W6CJ52	O94826
PDB IDs			7KDT
Enriched GO Terms of Interacting Partners?
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