PLA2R1 and SCN2A

Data Source:
HPRD (in vivo)

		PLA2R1	SCN2A
Description		phospholipase A2 receptor 1	sodium voltage-gated channel alpha subunit 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity
	Biological Process	Cytokine Production Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonic Acid Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Arachidonic Acid Secretion Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bilirubin levels ( 20639394) Blood protein levels ( 30072576 29875488) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 32231244 27333618) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990)	Adult body size ( 32376654) Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		2 interacting genes: PLA2G10 PLA2G2A	5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		22925	6326
HPRD ID		09222	03133
Ensembl ID		ENSG00000153246	ENSG00000136531
Uniprot IDs		B7ZML4 Q13018	Q99250
PDB IDs		6JLI	2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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