FGF6 and CELSR1

Data Source:
BioGRID (affinity chromatography technology)

		FGF6	CELSR1
Description		fibroblast growth factor 6	cadherin EGF LAG seven-pass G-type receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Sarcolemma	Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	MAPK Cascade Cartilage Condensation Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Myoblast Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Colorectal cancer ( 23263487) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Phosphorus levels ( 29403010 20558539) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Urate levels in obese individuals ( 25811787)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 NCALD	1 interacting genes: PSAP
Entrez ID		2251	9620
HPRD ID		00623	05160
Ensembl ID		ENSG00000111241	ENSG00000075275
Uniprot IDs		P10767	Q9NYQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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