FASN and BIRC5

Data Source:
BioGRID (biochemical)

		FASN	BIRC5
Description		fatty acid synthase	baculoviral IAP repeat containing 5
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GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex
	Molecular Function	RNA Binding [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding (3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity 3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity 3-oxo-glutaryl-[acp] Methyl Ester Reductase Activity 3-oxo-pimeloyl-[acp] Methyl Ester Reductase Activity	Protein Binding Microtubule Binding Enzyme Binding Small GTPase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding
	Biological Process	Osteoblast Differentiation Glandular Epithelial Cell Development Acetyl-CoA Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Ether Lipid Biosynthetic Process Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier	Protein Phosphorylation Apoptotic Process Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Protein-containing Complex Localization Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Cerulenin Orlistat	Reserpine Berberine LY2181308
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688) Refractive error ( 32231278)	Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		11 interacting genes: ADIPOQ AKT1 DUX4 EWSR1 LNX1 MTDH NDRG1 PRR12 PTEN SUMO2 YWHAQ	25 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 FBXL7 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 RAN RASA1 XIAP XPO1
Entrez ID		2194	332
HPRD ID		02567	04520
Ensembl ID		ENSG00000169710	ENSG00000089685
Uniprot IDs		P49327	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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