F2RL1 and JMY

Data Source:
BioGRID (biochemical)

		F2RL1	JMY
Description		F2R like trypsin receptor 1	junction mediating and regulatory protein, p53 cofactor
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Cell Leading Edge
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity	Transcription Coactivator Activity Actin Binding Protein Binding Arp2/3 Complex Binding
	Biological Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Chemokine Production Interferon-gamma Production Interleukin-1 Beta Production Interleukin-10 Production Negative Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Neutrophil Activation Vasodilation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	DNA Repair Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity 'de Novo' Actin Filament Nucleation Actin Polymerization-dependent Cell Motility Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)	Blood and toenail selenium levels ( 25343990) Platelet distribution width ( 32888494) Toenail selenium levels ( 25343990)
Interacting Genes		76 interacting genes: ABCC8 ABHD14A ADCY2 ARL6IP1 ATP2A2 ATP2B1 ATP2C1 BSG CANX CAPN1 CAPN2 CAPNS1 CBL CD63 CD81 CLPTM1 CNN3 COPS5 CRLS1 CTNNA1 CTSG DNMT3L ELANE ERGIC3 F2 GJB6 GJC2 GPRASP1 HERPUD1 HLA-E HMOX2 HSPA1B ICAM2 KDELR1 KLC1 LMNA MFSD10 MORN4 NAT14 NBPF15 OSTC P4HTM PHLDA1 PIGU PLG PPM1J PRNP PRRT2 PRTN3 PSMC3 PTDSS2 QSER1 R3HDM1 RGR RTN1 RTN4 SCN1B SDHD SLC12A5 SLC18B1 SLC1A4 SLC31A2 SLC32A1 SLC35A1 SLC39A13 SLC43A2 ST14 SYNGR2 TMBIM1 TMED1 TMEM161A TMEM62 TMX2 WFS1 YIPF1 YIPF6	8 interacting genes: CCDC136 EP300 GOLGA6L9 MDM2 MTUS2 RBM48 RINT1 TTC5
Entrez ID		2150	133746
HPRD ID		02960	05045
Ensembl ID		ENSG00000164251	ENSG00000152409
Uniprot IDs		P55085	Q8N9B5
PDB IDs		5NDD 5NDZ 5NJ6
Enriched GO Terms of Interacting Partners?
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