ALB and PDGFRA

Data Source:
BioGRID (affinity chromatography technology)

		ALB	PDGFRA
Description		albumin	platelet derived growth factor receptor alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Platelet Alpha Granule Lumen Protein-containing Complex Extracellular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Membrane Cell Junction Intrinsic Component Of Plasma Membrane Protein-containing Complex Receptor Complex
	Molecular Function	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Zinc Ion Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Pyridoxal Phosphate Binding Identical Protein Binding Chaperone Binding Exogenous Protein Binding Enterobactin Binding	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding
	Biological Process	Retina Homeostasis Platelet Degranulation Transport Receptor-mediated Endocytosis Cellular Response To Starvation High-density Lipoprotein Particle Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Cellular Protein Metabolic Process Maintenance Of Mitochondrion Location Cellular Oxidant Detoxification	MAPK Cascade Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis White Fat Cell Differentiation Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Amsacrine Cefotaxime Pyridostigmine Phenol Norelgestromin Aniline Guaiacol Artenimol Silver Patent Blue	Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases			Glioma
GWAS		Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Esterified cholesterol levels ( 29084231) Free cholesterol levels ( 29084231) Free cholesterol levels in large LDL ( 29084231) Large LDL particle concentration ( 29084231) Lipid metabolism phenotypes ( 22286219) Medium LDL particle concentration ( 29084231) Metabolite levels (small molecules and protein measures) ( 27005778) Prostate cancer ( 23535732) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 22144915 29422769) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 29403010 20139978) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 29403010 28453575 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		25 interacting genes: AGA AMBP APOE CRYAA CUBN F7 FCGRT HNF1A IMMT KLK3 LAMTOR5 LINC02582 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RYR2 SRGN ST13 TK1 YWHAG	64 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR EPHA2 ERBB2 ERBB3 FBXO25 FGFR4 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SLC9A3R1 SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		213	5156
HPRD ID		00062	01429
Ensembl ID		ENSG00000163631	ENSG00000134853
Uniprot IDs		P02768	P16234
PDB IDs		1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2N0X 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4BKE 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4K71 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9 4N0F 4N0U 4S1Y 4Z69 5FUO 5GIX 5GIY 5ID7 5IFO 5IJF 5UJB 5VNW 5X52 5YB1 5YOQ 5Z0B 6A7P 6EZQ 6HSC 6JE7 6L4K 6M58 6QIO 6QIP 6R7S 6WUW 6XV0 7JWN	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL
Enriched GO Terms of Interacting Partners?
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