EPHB4 and CLDN3

Data Source:
HPRD (in vitro)

		EPHB4	CLDN3
Description		EPH receptor B4	claudin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex Extracellular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Apical Junction Complex Tight Junction
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Epithelial Cell Morphogenesis Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Cell Junction Maintenance Maintenance Of Blood-brain Barrier Response To Ethanol Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Regulation Of Membrane Permeability Regulation Of Transepithelial Transport Positive Regulation Of Cell Junction Assembly Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Metallopeptidase Activity
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Tight junction interactions
Drugs		Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Blond vs. brown/black hair color ( 30531825) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Platelet distribution width ( 32888494) Resting heart rate ( 27798624)	Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		5 interacting genes: APP EFNB2 FBXO7 GRIN1 SDC3	7 interacting genes: APP CLDN1 CLDN5 POM121 PRKACA TJP1 WNK4
Entrez ID		2050	1365
HPRD ID		02481	04219
Ensembl ID		ENSG00000196411	ENSG00000165215
Uniprot IDs		P54760 Q541P7 Q96L35	O15551 Q75L79
PDB IDs		2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM
Enriched GO Terms of Interacting Partners?
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