EGR4 and GPX4

Data Source:
BioGRID (biochemical)

		EGR4	GPX4
Description		early growth response 4	glutathione peroxidase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		NGF-stimulated transcription	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs			Glutathione Glutathione Glutathione disulfide
Diseases
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656)	Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ABI2 BAG3 CRBN DNMT3L NFATC2	3 interacting genes: MAPK13 PARK7 PRDX6
Entrez ID		1961	2879
HPRD ID		00550	11819
Ensembl ID		ENSG00000135625	ENSG00000167468
Uniprot IDs		B7ZKU3 Q05215	P36969 Q6PI42
PDB IDs			2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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