EEF1B2 and CFLAR

Data Source:
BioGRID (affinity chromatography technology)

		EEF1B2	CFLAR
Description		eukaryotic translation elongation factor 1 beta 2	CASP8 and FADD like apoptosis regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function	Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Translational Elongation Regulation Of Catalytic Activity	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Cellular Response To Insulin Stimulus Response To Testosterone Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Execution Phase Of Apoptosis Negative Regulation Of Myoblast Fusion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Eukaryotic Translation Elongation	TRAIL signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)
Interacting Genes		13 interacting genes: AARS1 APP CSNK2A1 CSNK2A2 DRD3 EEF1G HARS1 SPRYD4 TIMP1 TPT1 ULK2 VHL WBP2	25 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8
Entrez ID		1933	8837
HPRD ID		02804	04671
Ensembl ID		ENSG00000114942	ENSG00000003402
Uniprot IDs		A0A024R3W7 P24534	A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		1B64 5DQS	2N5R 3H11 3H13
Enriched GO Terms of Interacting Partners?
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