DPAGT1 and THTPA

Data Source:
BioGRID (biochemical)

		DPAGT1	THTPA
Description		dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	thiamine triphosphatase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity Transferase Activity, Transferring Glycosyl Groups Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Binding Hydrolase Activity Thiamin-triphosphatase Activity
	Biological Process	UDP-N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Dolichol Metabolic Process	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Dephosphorylation Thiamine Diphosphate Metabolic Process Thiamine-containing Compound Metabolic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2	Vitamin B1 (thiamin) metabolism
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		2 interacting genes: LSM8 MFSD3	1 interacting genes: TLX3
Entrez ID		1798	79178
HPRD ID		01879	15505
Ensembl ID		ENSG00000172269	ENSG00000259431
Uniprot IDs		A0A024R3H8 Q9H3H5	G3V5Q5 Q9BU02
PDB IDs		5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3	3BHD 3TVL
Enriched GO Terms of Interacting Partners?
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