DNASE2 and DNMT1

Data Source:
BioGRID (biochemical)

		DNASE2	DNMT1
Description		deoxyribonuclease 2, lysosomal	DNA methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Deoxyribonuclease II Activity	DNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding
	Biological Process	DNA Metabolic Process Apoptotic DNA Fragmentation Erythrocyte Differentiation Regulation Of Immune Response	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation C-5 Methylation Of Cytosine Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Lysosome Vesicle Biogenesis	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs			Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Immature fraction of reticulocytes ( 27863252) Mean corpuscular volume ( 29403010) Red cell distribution width ( 28957414)	Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		1 interacting genes: XRN1	41 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EZH2 GSK3B H3-4 H3C1 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MECP2 NRIP1 PCLAF PCNA PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUMO2 SUV39H1 TRIM27 TSG101 UBB UHRF1 YWHAQ
Entrez ID		1777	1786
HPRD ID		00531	00532
Ensembl ID		ENSG00000105612	ENSG00000130816
Uniprot IDs		A0A024R7F4 O00115	I6L9H2 P26358 Q59FP7
PDB IDs			3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A
Enriched GO Terms of Interacting Partners?
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