DNASE1L3 and IMPDH2

Data Source:
BioGRID (biochemical)

		DNASE1L3	IMPDH2
Description		deoxyribonuclease 1 like 3	inosine monophosphate dehydrogenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding Deoxyribonuclease I Activity Deoxyribonuclease Activity Calcium Ion Binding Protein Binding	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Metal Ion Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Programmed Cell Death Involved In Cell Development Regulation Of Neutrophil Mediated Cytotoxicity	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation
Pathways			Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Eating disorders (purging via substances) ( 23568457) Height ( 28552196) Limited cutaneous systemic scleroderma ( 24387989) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic sclerosis ( 28314753 24387989 31672989 30572963) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: CYSRT1 KRTAP5-9	15 interacting genes: AGR2 AKT1 ANKRD9 APIP CLK1 CPLANE2 IL1F10 IMPDH1 PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		1776	3615
HPRD ID		03764	00895
Ensembl ID		ENSG00000163687	ENSG00000178035
Uniprot IDs		A0A024R365 Q13609	A0A384N6C2 P12268
PDB IDs			1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ
Enriched GO Terms of Interacting Partners?
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