DNAH5 and RAN

Data Source:
BioGRID (proximity labelling technology)

		DNAH5	RAN
Description		dynein axonemal heavy chain 5	RAN, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Microtubule Axoneme Dynein Complex Motile Cilium Outer Dynein Arm 9+2 Motile Cilium	Chromatin Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Melanosome RNA Nuclear Export Complex Host Cell Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding GDP Binding Cadherin Binding Protein Heterodimerization Activity Pre-miRNA Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle DNA Metabolic Process TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization MiRNA Metabolic Process Viral Process Positive Regulation Of Protein Binding Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Regulation Of Cholesterol Biosynthetic Process GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Intracellular Transport Of Virus Protein Localization To Nucleolus
Pathways			Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs			Guanosine-5'-Diphosphate
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Coffee consumption ( 29367735) Corneal astigmatism ( 23322567) Emphysema imaging phenotypes ( 26030696) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) IgE grass sensitization ( 22036096) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Subclinical atherosclerosis traits (other) ( 17903303) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689) Visceral fat ( 22589738)
Interacting Genes		1 interacting genes: MTDH	58 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L DUX4 EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 SUMO2 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		1767	5901
HPRD ID		04514	03109
Ensembl ID		ENSG00000039139	ENSG00000132341
Uniprot IDs		Q8TE73	B4DV51 P62826
PDB IDs			1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6KFT 6Q82 6Q84 6TVO 6X2M 6X2O 6X2P 6X2R 6X2S 6X2U 6X2V 6X2W 6X2X 6X2Y
Enriched GO Terms of Interacting Partners?
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