GSDME and GPNMB

Data Source:
BioGRID (proximity labelling technology)

		GSDME	GPNMB
Description		gasdermin E	glycoprotein nmb
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Melanosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity
	Biological Process	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			PTK6 promotes HIF1A stabilization
Drugs			Glembatumumab vedotin
Diseases		Deafness, autosomal dominant
GWAS			Blood protein levels ( 30072576 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Iron status biomarkers (transferrin saturation) ( 28334935) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		3 interacting genes: ITGB1BP1 PTN TIFA	4 interacting genes: EGFR ITSN2 LINC01139 SMAD4
Entrez ID		1687	10457
HPRD ID		02996	05081
Ensembl ID		ENSG00000105928	ENSG00000136235
Uniprot IDs		A0A024RA58 A4FVA8 O60443	A0A024RA55 Q14956 Q96F58
PDB IDs
Enriched GO Terms of Interacting Partners?
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