DAP and DNAH5

Data Source:
BioGRID (genetic interference)

		DAP	DNAH5
Description		death associated protein	dynein axonemal heavy chain 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Microtubule Axoneme Dynein Complex Motile Cilium Outer Dynein Arm 9+2 Motile Cilium
	Molecular Function	Death Domain Binding	ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Autophagy Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Amino Acid Starvation Negative Regulation Of Transcription, DNA-templated Apoptotic Signaling Pathway	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Gut microbiota (functional units) ( 27694959) Height ( 28270201) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Metabolite levels (Pyroglutamine) ( 23934736) Pulse pressure ( 27841878) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ulcerative colitis ( 21297633)	Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Coffee consumption ( 29367735) Corneal astigmatism ( 23322567) Emphysema imaging phenotypes ( 26030696) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) IgE grass sensitization ( 22036096) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Subclinical atherosclerosis traits (other) ( 17903303) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689) Visceral fat ( 22589738)
Interacting Genes		1 interacting genes: SETDB1	1 interacting genes: MTDH
Entrez ID		1611	1767
HPRD ID		02977	04514
Ensembl ID		ENSG00000112977	ENSG00000039139
Uniprot IDs		B4DQ75 P51397	Q8TE73
PDB IDs
Enriched GO Terms of Interacting Partners?
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