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CYP27B1 and MYL6
Data Source:
BioGRID
(x-ray crystallography, biochemical)
HPRD
(in vitro)
CYP27B1
MYL6
Description
cytochrome P450 family 27 subfamily B member 1
myosin light chain 6
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Brush Border
Membrane
Myosin Complex
Unconventional Myosin Complex
Vesicle
Extracellular Exosome
Molecular Function
Calcidiol 1-monooxygenase Activity
Iron Ion Binding
Heme Binding
Secalciferol 1-monooxygenase Activity
Motor Activity
Calcium Ion Binding
Protein Binding
Structural Constituent Of Muscle
Actin-dependent ATPase Activity
Biological Process
Vitamin Metabolic Process
Calcium Ion Transport
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Positive Regulation Of Vitamin D 24-hydroxylase Activity
Bone Mineralization
Negative Regulation Of Cell Growth
Regulation Of Bone Mineralization
Response To Lipopolysaccharide
Response To Vitamin D
Response To Interferon-gamma
Calcitriol Biosynthetic Process From Calciol
Vitamin D Metabolic Process
Vitamin D Catabolic Process
Response To Estrogen
Positive Regulation Of Keratinocyte Differentiation
Decidualization
Calcium Ion Homeostasis
G1 To G0 Transition
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Muscle Contraction
Skeletal Muscle Tissue Development
Muscle Filament Sliding
Pathways
Vitamin D (calciferol) metabolism
Vitamins
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
EPHA-mediated growth cone collapse
Sema4D induced cell migration and growth-cone collapse
Smooth Muscle Contraction
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
Drugs
Alfacalcidol
Diseases
Type I diabetes mellitus
GWAS
Brain morphology (MOSTest) (
32665545
)
Multiple sclerosis (
19525955
21833088
)
Asthma (
31619474
)
Interacting Genes
7 interacting genes:
ADAMTS12
DNAJB9
EWSR1
GLP1R
MLH1
MOB4
NUDT21
Entrez ID
1594
4637
HPRD ID
02031
17618
Ensembl ID
ENSG00000111012
ENSG00000092841
Uniprot IDs
O15528
P60660
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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